The royal figure gives up his designation as Duke of York.
The royal is relinquishing his titles, including the York's Duke, he has announced in a own words.
He has been under mounting pressure over his connections with sex offender Jeffrey Epstein, with calls for the royal household to take measures against him.
That now appears to have resulted in the royal deciding to willingly return his designations and to give up membership of the Order of the Garter.
In his announcement he said he continued to "strongly deny the allegations against me".
"In talks with the King, and my immediate and wider family, we have agreed the ongoing allegations about me distract from the responsibilities of His Majesty and the monarchy," said a announcement from the royal.
"I have decided, as I always have, to put my responsibility to my kin and country first.
"I support my decision five years ago to stand back from royal engagements.
"With the King's approval, we think I must now go a additional measure. I will therefore no longer use my title or the honours which have been bestowed on me. As I have said previously, I strongly dispute the accusations against me."
The royal has encountered a range of scandals, including a court case he ended with Virginia Giuffre, questions about his economic affairs and his involvement with an alleged Chinese spy.
He will remain a royal - but will discontinue to be the the Duke, a designation granted from his parent, the late Queen Elizabeth.
He had already stopped to be a "working royal" and had forfeited the use of his His Royal Highness designation and no longer was seen at state occasions. His position now will be even more diminished.
His former spouse will be known as Ferguson and no longer the Duchess, but their daughters will carry on to have the title of princesses.
Prince Andrew has faced severe attention over his associations with convicted sex offender Epstein, more in recent times featuring questions about when he had really severed communication.
In his television appearance, the royal had said that he had severed all ties with the financier after they had been photographed together in New York in late 2010.
But emails sent in February 2011 later came to light suggesting that Andrew had privately continued in touch with the financier, such as exchanging a communication: "Keep in close touch and we'll meet again soon!"
There had been increasing displeasure in the royal household at the scandals that remained to surround the royal.
Next week a posthumous memoir by the accuser will be published which is likely to draw additional attention on Prince Andrew's involvement with the plaintiff and Jeffrey Epstein.
